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Type 2 Diabetes & Obesity (Unified Protocol) Starting Dose: 0.25 mg once weekly Titration: Increase every 4 weeks as tolerated ( 0.5 mg 1.0 mg 1.7 mg 2.4 mg) Common Dose: 1.02.0 mg weekly Maximum Dose: 2.4 mg weekly Recommended Dosage Table Possible Adverse Reactions Gastrointestinal: nausea, vomiting, diarrhea, abdominal pain (especially during titration) Hypoglycemia: low risk alone

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In vitro studies have shown that dexamethasone treatment of At-T20 corticotroph tumor cells induced significant suppression of SSTR2 messenger ribonucleic acid (mRNA) expression ( in vitro ( The glucocorticoid receptor (GR) antagonist mifepristone, a non-selective steroidal GR antagonist with progesterone receptor activity, has been shown to reverse the inhibitory effects of glucocorticoids on SSTR2 mRNA expression in the human neuroendocrine cell lines BON (carcinoid) and TT (medullary thyroid carcinoma) ( in vitro effects of mifepristone on SSTR2 expression in corticotroph tumor cell lines have not been studied